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Of interest, the mRNA expression of both PINK1, a marker not significantly different in CSE exposed BEAS-2B cells (Online Additional file 1), and PPARGC1, a marker that was not detectable in CSE exposed BEAS-2B cells, was significantly increased in PBECs from COPD patients when compared to non-smoking controls (Figure 5B)

But behind the stable headline number lies a deeper shift

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Freddie Prinze, 22, died Jan

Key Takeaways From April 2026 , Denmark introduced major restrictions on nicotine pouches: only tobacco and menthol flavours are now permitted for sale all fruit, candy, and other flavours are banned